Mayol Llinas, J, Chow, S orcid.org/0000-0002-3600-0497 and Nelson, A (2019) Expansion of the structure–activity relationships of BACE1 inhibitors by harnessing diverse building blocks prepared using a unified synthetic approach. MedChemComm, 10 (4). pp. 616-620. ISSN 2040-2503
Abstract
The structural diversity of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors was expanded by harnessing diverse building blocks that had been prepared via a unified lead-oriented synthetic approach. It was shown that the lipophilic cyclohexylmethyl group within a known series of BACE1 inhibitors could be productively replaced with a range of alternative ring systems.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2019. This is an author produced version of a paper published in MedChemComm. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Funding Information: | Funder Grant number EPSRC EP/N025652/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Mar 2019 11:04 |
Last Modified: | 22 Mar 2020 01:38 |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/C9MD00085B |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143709 |