Khot, MI orcid.org/0000-0002-5062-2284, Andrew, H, Svavarsdottir, HS et al. (3 more authors) (2019) A Review on the Scope of Photothermal Therapy–Based Nanomedicines in Preclinical Models of Colorectal Cancer. Clinical Colorectal Cancer, 18 (2). e200-e209. ISSN 1533-0028
Abstract
Oncologic thermal ablation involves the use of hyperthermic temperatures to damage and treat solid cancers. Thermal ablation is being investigated as a method of treatment in colorectal cancers and has the potential to complement conventional anticancer treatments in managing local recurrence and metastatic disease. Photothermal therapy utilizes photosensitive agents to generate local heat and induce thermal ablation. There is growing interest in developing nanotechnology platforms to deliver such photosensitive agents. An advantage of nanomedicines is their multifunctionality, with the capability to deliver combinations of chemotherapeutics and cancer-imaging agents. To date, there have been no clinical studies evaluating photothermal therapy–based nanomedicines in colorectal cancers. This review presents the current scope of preclinical studies, investigating nanomedicines that have been developed for delivering multimodal photothermal therapy to colorectal cancers, with an emphasis on potential clinical applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Elsevier Inc. This is an author produced version of a paper published in Clinical Colorectal Cancer. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Nanoparticles; Optical imaging; Photosensitive agent; Targeted therapy; Thermal ablation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) > Trans Anaesthetics & Surgical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 Mar 2019 11:44 |
Last Modified: | 14 Feb 2020 01:39 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.clcc.2019.02.001 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143600 |