Knowles, RL, Ridout, D, Crowe, S et al. (7 more authors) (2019) Ethnic-specific mortality of infants undergoing congenital heart surgery in England and Wales. Archives of Disease in Childhood, 104 (9). pp. 844-850. ISSN 0003-9888
Abstract
Purpose: To investigate ethnic differences in mortality for infants with congenital heart defects (CHDs) undergoing cardiac surgery or interventional catheterisation.
Design: Observational study of survival to age 1 year using linked records from routine national paediatric cardiac surgery and intensive care audits. Mortality risk was investigated using multivariable Poisson models with multiple imputation. Predictors included sex, ethnicity, preterm birth, deprivation, comorbidities, prenatal diagnosis, age and weight at surgery, preprocedure deterioration and cardiac diagnosis.
Setting: All paediatric cardiac surgery centres in England and Wales.
Patients: 5350 infants with CHDs born from 2006 to 2009.
Main outcome measure: Survival at age 1 year.
Results: Mortality was 83.9 (95% CI 76.3 to 92.1) per 1000 infants, with variation by ethnic group. Compared with those of white ethnicity, infants in British Asian (Indian, Pakistani and Bangladeshi) and ‘all other’ (Chinese, mixed and other) categories experienced significantly higher mortality by age 1 year (relative risk [RR] 1.52[95% CI 1.19 to 1.95]; 1.62[95% CI 1.20 to 2.20], respectively), specifically during index hospital admission (RR 1.55 [95% CI 1.07 to 2.26]; 1.64 [95% CI 1.05 to 2.57], respectively). Further predictors of mortality included non-cardiac comorbidities, prenatal diagnosis, older age at surgery, preprocedure deterioration and cardiac diagnosis. British Asian infants had higher mortality risk during elective hospital readmission (RR 1.86 [95% CI 1.02 to 3.39]).
Conclusions: Infants of British Asian and ‘all other’ non-white ethnicity experienced higher postoperative mortality risk, which was only partly explained by socioeconomic deprivation and access to care. Further investigation of case-mix and timing of risk may provide important insights into potential mechanisms underlying ethnic disparities.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. This article has been accepted for publication in Archives of Disease in Childhood 2019 following peer review, and the Version of Record can be accessed online at https://doi.org/10.1136/archdischild-2018-315505. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) http://creativecommons.org |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Clinical & Population Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Mar 2019 11:39 |
Last Modified: | 02 Sep 2019 09:58 |
Status: | Published |
Publisher: | BMJ Publishing Group |
Identification Number: | 10.1136/archdischild-2018-315505 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143569 |
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