Linney, LS, Al-Hassani, F, Pikturnaite, J et al. (4 more authors) (2019) Tenosynovial giant cell tumours of the hand: A multicentre case-control study. Journal of Plastic, Reconstructive & Aesthetic Surgery, 72 (6). pp. 918-923. ISSN 1748-6815
Abstract
Many factors have been proposed to contribute to the risk of recurrent tenosynovial giant cell tumours (TSGCT); however, we remain unable to predict those at risk, which formed the rationale for this multicentre retrospective case-control study of 28 patients with recurrence. We included cases of recurrence in a 1:1 ratio matched for age and sex with controls over 10 years. Using Cox regression, we present hazard ratios (HRs) for recurrence with 95% confidence intervals (CIs). Out of 285 cases, 28 individuals developed recurrence after a median of 2.4 years. Recurrent TSGCT had a higher mitotic count/mm2 in the primary tumour (median increase of 3 [IQR 1, 7]). Mitotic count in the primary tumour was associated with the risk of recurrence (adjusted HR 1.1 [95% CI 1.1, 1.2]) meaning that for every additional mitosis, the risk of recurrence increased by 10% per annum. We recommend a prospective cohort study to validate our findings.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. This is an author produced version of a paper published in Journal of Plastic, Reconstructive & Aesthetic Surgery. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | TSGCT; GCTTS; Giant cell tumours; Tumours of the hand |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) > Trans Anaesthetics & Surgical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Mar 2019 11:55 |
Last Modified: | 01 Feb 2020 01:39 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.bjps.2019.01.021 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143435 |