Sombra, FM, Richter, AR, Rodrigues de Araújo, A et al. (8 more authors) (2019) Nanocapsules of Sterculia striata acetylated polysaccharide as a potential monomeric amphotericin B delivery matrix. International Journal of Biological Macromolecules, 130. pp. 655-663. ISSN 0141-8130
Abstract
Stable oil nanocapsules based on acetylated Sterculia striata polysaccharide (ASSP) were produced without the use of a surfactant, and derivatives of ASSP with four different degrees of substitution (DS) were synthesised. The data revealed that only derivatives with high DS were able to produce nanocapsules (NC), which exhibited monomodal size distribution profiles with a Z-average particle size, ζ-potential, and polydispersity index (PDI) that were dependent on ASSP DS and concentration. Nanocapsules were loaded with amphotericin B (AMB) with encapsulation efficiencies (EE%) thatwere dependent on drug and ASSP concentrations and DS. A maximum EE% value of 99.2%was achieved, and the loaded AMBwas found to be in amonomeric form, evenwith a concentration one hundredfold higher than that usually observed for commercial AMB aqueous solutions. Loaded nanocapsules show an in vitro controlled release of AMB. As the monomeric AMB state decreased drug toxicity, ASSP nanocapsules loaded with AMB (NC1.68) have potential for use as a drug delivery system. AMB loaded NC 1.68 keeps its activity against 5 strains of Candida albicans tested.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | (c) 2019, Elsevier Ltd. All rights reserved. This is an author produced version of a paper published in International Journal of Biological Macromolecules. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Acetylated derivatives, Sterculia striata, nanocapsules, amphotericin B |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 08 Mar 2019 10:56 |
Last Modified: | 21 Feb 2020 01:38 |
Status: | Published |
Publisher: | Elsevier BV |
Identification Number: | 10.1016/j.ijbiomac.2019.02.076 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143428 |