Alves, Joel M., Carneiro, Miguel, Cheng, Jade Y. et al. (25 more authors) (2019) Parallel adaptation of rabbit populations to myxoma virus. Science. ISSN 0036-8075
Abstract
In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased its antiviral effect.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Arts and Humanities (York) > Archaeology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 06 Mar 2019 09:50 |
Last Modified: | 08 Feb 2025 00:33 |
Published Version: | https://doi.org/10.1126/science.aau7285 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1126/science.aau7285 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143315 |
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