McLeish, Tom orcid.org/0000-0002-2025-0299, Schaefer, C. and von der Heydt, A. C. (2018) The ‘allosteron’ model for entropic allostery of self-assembly. Philosophical Transactions of the Royal Society B: Biological Sciences. 20170186. ISSN 1471-2970
Abstract
Using the simple ‘allosteron’ model, we show that it is possible, in principle, to elicit pathways by which fluctuation allostery affects self-assembly of protein complexes. We treat the cases of (i) protein fibrils and nucleation, (ii) n-mer protein complexes, and (iii) weakly attractive allosteric interactions in protein-like soft nanoscale objects that can be tuned to define exclusive self-associating families. This article is part of a discussion meeting issue ‘Allostery and molecular machines’.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Author(s) |
Keywords: | Allostery,Ligand-binding,Self-assembly |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Physics (York) |
Depositing User: | Pure (York) |
Date Deposited: | 28 Feb 2019 14:50 |
Last Modified: | 21 Jan 2025 17:35 |
Published Version: | https://doi.org/10.1098/rstb.2017.0186 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1098/rstb.2017.0186 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143107 |