Moore, JB orcid.org/0000-0003-4750-1550 (2019) From sugar to liver fat and public health: Systems biology driven studies in understanding non-alcoholic fatty liver disease pathogenesis. In: Proceedings of the Nutrition Society. Nutrition Society Summer Meeting 2018, 10-12 Jul 2018 Cambridge University Press , pp. 290-304.
Abstract
Non-alcoholic fatty liver (NAFLD) disease is now a major public health concern with an estimated prevalence of 25-30% of adults in many countries. Strongly associated with obesity and the metabolic syndrome, the pathogenesis of NAFLD is dependent on complex interactions between genetic and environmental factors that are not completely understood. Weight loss through diet and lifestyle modification underpins clinical management; however, the roles of individual dietary nutrients (e.g. saturated and omega-3 fatty acids; fructose, vitamin D, vitamin E) in the pathogenesis or treatment of NAFLD are only partially understood. Systems biology offers valuable interdisciplinary methods that are arguably ideal for application to the studying of chronic diseases such as NAFLD, and the roles of nutrition and diet in their molecular pathogenesis. Although current in silico models are incomplete, computational tools are rapidly evolving and human metabolism can now be simulated at the genome scale. This article will review NAFLD and its pathogenesis, including the roles of genetics and nutrition in the development and progression of disease. In addition, the article introduces the concept of systems biology and reviews recent work utilising genome-scale metabolic networks (GSMNs) and developing multi-scale models of liver metabolism relevant to NAFLD. A future is envisioned where individual genetic, proteomic and metabolomic information can be integrated computationally with clinical data, yielding mechanistic insight into the pathogenesis of chronic diseases such as NAFLD, and informing personalized nutrition and stratified medicine approaches for improving prognosis.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author 2019. This is an author produced version of a paper published for publication in Proceedings of the Nutrition Society . Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Non-alcoholic fatty liver disease: Obesity: Sugar: Stratified medicine: Personalised nutrition: Genome-scale metabolic networks |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Feb 2019 14:09 |
Last Modified: | 15 Aug 2019 11:10 |
Status: | Published |
Publisher: | Cambridge University Press |
Identification Number: | 10.1017/S0029665119000570 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143046 |