Stacey, G.N., Andrews, P. orcid.org/0000-0001-7215-4410, Barbaric, I. et al. (17 more authors) (2019) Stem cell culture conditions and stability: a joint workshop of the PluriMes Consortium and Pluripotent Stem Cell Platform. Regenerative Medicine, 14 (3). pp. 243-255. ISSN 1746-0751
Abstract
Human stem cells have the potential to transform medicine. However, hurdles remain to ensure that manufacturing processes produce safe and effective products. A thorough understanding of the biological processes occurring during manufacture of what can be very complex products, is fundamental to assuring these qualities and thus, their acceptability to regulators and clinicians. Leaders in both human pluripotent and somatic stem cells, were brought together with experts in clinical translation, bio-manufacturing and regulation, to discuss key issues in assuring appropriate manufacturing conditions for delivery of effective and safe products from these cell types. This report summarizes the key issues discussed and records consensus reached by delegates and emphasizes the need for accurate language and nomenclature in the scientific discourse around stem cells.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2019 Stacey, Andrews, Barbaric et al. This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
Keywords: | Cell therapy; pluripotent stem cells; mesenchymal cells; clinical trial; characterization regulation; manufacturing; regenerative medicine; cell-based medicines |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION - FP6/FP7 PLURIMES - 602423 MEDICAL RESEARCH COUNCIL MR/L012537/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 26 Feb 2019 15:02 |
Last Modified: | 08 May 2019 13:35 |
Status: | Published |
Publisher: | Future Medicine |
Refereed: | Yes |
Identification Number: | 10.2217/rme-2019-0001 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143000 |