Selby, P, Liu, L, Downing, A orcid.org/0000-0002-0335-7801 et al. (10 more authors) (2019) How can clinical research improve European health outcomes in cancer? Journal of Cancer Policy, 20. ARTN 100182. ISSN 2213-5383
Abstract
We review the mechanisms by which clinical cancer research can improve health outcomes and argue that this should be central to the development of policy. Recent series of major international studies have analysed large, often nationwide, datasets for cancer patient outcomes and participation in clinical research. They have evaluated and quantified the impact of new evidence generated by randomised controlled trials on cancer survival. They show a strong and probably causal relationship between the participation in clinical research in hospitals and the outcomes for patients with the disease under study in those hospitals. Also, institutions that are active in clinical trials appear to take up well evidenced innovations more rapidly than those which are not so engaged. Further work is necessary to confirm and examine the generalisability of these findings but we argue that all of these mechanisms are likely to lead to improved outcomes for patients as a consequence of the conduct of clinical research. The size of the benefit appears to be substantial and an active programme to promote clinical research across cancer care systems should be a part of National Cancer Plans and Cancer Control Strategies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Elsevier Ltd. All rights reserved. This is an author produced version of a paper published in Journal of Cancer Policy. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Clinical Cancer Research (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Epidemiology and Biostatistics (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Clinical Trials Research (LICTR) (Leeds) |
Funding Information: | Funder Grant number Cancer Research UK C588/A4994 Cancer Research UK 38111 Cancer Research UK CRUK 04 05 BUDGET Cancer Research UK CRUK 05 06 BUDGET Cancer Research UK C588/A4994 Cancer Research UK CRUK 05 06 BUDGET Cancer Research UK C6003/A7686 Department of Health NCRN CC Leeds Teaching Hospitals Charitable Foundation 4616 Cancer Research UK A24939 |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Feb 2019 10:55 |
Last Modified: | 01 Feb 2020 01:39 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jcpo.2019.100182 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:142869 |
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Filename: Outcomes review Journal of Cancer Policy Dec 2018.pdf
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