Reglinski, M., Sriskandan, S. and Turner, C. orcid.org/0000-0002-4458-9748 (2019) Identification of two new core chromosome-encoded superantigens in Streptococcus pyogenes; speQ and speR. Journal of Infection, 78 (5). pp. 358-363. ISSN 0163-4453
Abstract
Superantigens are ubiquitous within the Streptococcus pyogenes genome, which suggests that superantigen-mediated T-cell activation provides a significant selective advantage. S. pyogenes can carry a variable complement of the 11 known superantigens. We have identified two novel S. pyogenes superantigens, denoted speQ and speR, adjacent to each other in the core-chromosome of isolates belonging to eleven different emm-types. Although distinct from other superantigens, speQ and speR were most closely related to speK and speJ respectively. Recombinant SPEQ and SPER were mitogenic towards human peripheral blood mononuclear cells at ng/ml concentrations, and SPER was found to be more mitogenic than SPEQ.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2019 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/) |
Keywords: | Streptococcus pyogenes; group A Streptococcus; superantigens; scarlet fever; toxic shock syndrome; mitogen |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Mar 2019 13:22 |
Last Modified: | 18 Nov 2021 11:42 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.jinf.2019.02.005 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:142818 |