Miles, JA orcid.org/0000-0001-8839-9201, Machattou, P, Nevin-Jones, D et al. (4 more authors) (2019) Identification of a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro. Biochemical and Biophysical Research Communications, 510 (1). pp. 27-34. ISSN 0006-291X
Abstract
Retinoic acid signalling is generally considered to be of animal origin. Recently, retinoic acid has been identified in cyanobacteria, yet no mechanism for its production has been identified. Here, we characterise for the first time a cyanobacterial aldehyde dehydrogenase that produces retinoic acid in vitro. Our computational studies suggest that the cyanobacterial aldehyde dehydrogenase resembles an ancestor of both eukaryotic aldehyde dehydrogenase 1 and aldehyde dehydrogenase 2. The Chlorogloeopsis fritschii aldehyde dehydrogenase described here may find applications in synthetic production of retinoic acid as well as contributing to our understanding of retinoid synthesis in cyanobacteria.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Elsevier Inc. All rights reserved. This is an author produced version of a paper published in Biochemical and Biophysical Research Communications. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Aldehyde dehydrogenase; Cyanobacteria; Lateral gene transfer; Retinoic acid |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biology (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Feb 2019 14:04 |
Last Modified: | 17 Jan 2020 01:40 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.bbrc.2018.12.171 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:142452 |
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