Wang, C, Zhou, L, Zhang, X et al. (3 more authors) (2018) The Role of Solvent Composition and Polymorph Surface Chemistry in the Solution-Mediated Phase Transformation Process of Cefaclor. Industrial & Engineering Chemistry Research, 57 (49). pp. 16925-16933. ISSN 0888-5885
Abstract
The solution-mediated phase transformation process from cefaclor dihydrate to an ethanol–water solvate is analyzed by optical microscopy, powder X-ray diffraction, scanning electron microscopy and molecular modeling. The solution concentration and polymorphic composition during slurry transformation, as monitored using UV and Raman spectroscopy, respectively, reveal that the dihydrate transforms to the ethanol–water solvate at a low ethanol concentration in the mixture solvent. The transformation process is controlled by the growth of ethanol–water solvate, which nucleates on the surfaces of the dihydrate crystals. Molecular simulation confirms the critical point of transformation between the dihydrate and the ethanol–water solvate, consistent with the experimental results. The results demonstrate the importance of the solvent composition and surface chemistry of dihydrate in promoting the heterogeneous nucleation of ethanol–water solvate and provide guidance for the process control for the target form of cefaclor required.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Copyright © 2018 American Chemical Society. This is an author produced version of a paper published in Industrial & Engineering Chemistry Research. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Funding Information: | Funder Grant number EPSRC EP/I014446/1 EPSRC EP/I013563/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Feb 2019 10:59 |
Last Modified: | 16 Nov 2019 01:39 |
Status: | Published |
Publisher: | American Chemical Society |
Identification Number: | 10.1021/acs.iecr.8b04462 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:142277 |