Justo, N., Espinoza, M., Ratto, B. et al. (7 more authors) (2019) Real-World Evidence in Healthcare Decision Making:Global trends and case studies from Latin America. Value in Health. pp. 739-749. ISSN 1524-4733
Abstract
Objectives: Real-world evidence (RWE) is increasingly used to inform health technology assessments (HTAs) for resource allocation, which are valuable tools for emerging economies such as in America. However, the characteristics and uses in South America are unknown. This study aims to identify sources, characteristics and uses of RWE in Argentina, Brazil, Colombia and Chile, and evaluate the context-specific challenges. The implications for future regulation and responsible management of RWE in the region are also considered. Methods: A systematic literature review, database mapping, and targeted grey literature search were conducted to identify the sources and characteristics of RWE. Findings were validated by key opinion leaders attending workshops in four South American countries. Results: A database mapping exercise revealed 407 unique databases. Geographic scope, database type, population and outcomes captured were reported. Characteristics of National Health Information Systems show efforts to collect interoperable data from service providers, insurers and government agencies, but that initiatives are hampered by fragmentation, lack of stewardship and resources. RWE is mainly used in South America for pharmacovigilance and as pure academic research, but less so for HTA decision-making or pricing negotiations and not at all to inform early access schemes. Conclusions: The quality of data collected in real-world in the case-study countries varies and RWE is not consistently used in healthcare decision-making. Authors recommend that future studies monitor the impact of digitalisation, and the potential effects of access to RWE on the quality of patient care.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019, ISPOR–The Professional Society for Health Economics and Outcomes Research. Published by Elsevier Inc |
Keywords: | big data,epidemiology,health policy,Health Technology Assessment,Latin America,real-world evidence |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Social Sciences (York) > Economics and Related Studies (York) The University of York > Faculty of Social Sciences (York) > Centre for Health Economics (York) |
Depositing User: | Pure (York) |
Date Deposited: | 01 Feb 2019 10:50 |
Last Modified: | 16 Oct 2024 15:26 |
Published Version: | https://doi.org/10.1016/j.jval.2019.01.014 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.jval.2019.01.014 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:141890 |
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