Rasheed, H orcid.org/0000-0003-2983-6867, Kay, P, Slack, R et al. (1 more author) (2018) Assessment of arsenic species in human hair, toenail and urine and their association with water and staple food. Journal of Exposure Science & Environmental Epidemiology, 29. pp. 624-632. ISSN 1559-0631
Abstract
Arsenic intake from household drinking/cooking water and food may represent a significant exposure pathway to induce cancer and non-cancer health effects. This study is based on the human biomonitoring of 395 volunteers from 223 households with private water sources located in rural Punjab, Pakistan. This work has shown the relative contribution of water and staple food to arsenic intake and accumulation by multiple biological matrix measurements of inorganic and organic arsenic species, while accounting for potential confounders such as age, gender, occupation, and exposure duration of the study population. Multi-variable linear regression showed a strong significant relationship between total arsenic (tAs) intake from water and concentrations of tAs, inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA) in urine and toenail samples. tAs intake from staple food (rice and wheat) also showed a strong significant relationship with hair tAs and iAs. The sole impact of staple food intake on biomarkers was assessed and a significant correlation was found with all of the urinary arsenic metabolites. Toenail was found to be the most valuable biomarker of past exposure to inorganic and organic arsenic species of dietary and metabolic origin.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018, Springer Nature America, Inc. This is a post-peer-review, pre-copyedit version of an article published in Journal of Exposure Science & Environmental Epidemiology. The final authenticated version is available online at: https://doi.org/10.1038/s41370-018-0056-7. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Monomethylarsonic acid; Dimethylarsonic acid; Toenail arsenic; Dietary exposure; Urinary arsenic metabolites |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Geography (Leeds) > River Basin Processes & Management (Leeds) The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 Jan 2019 15:08 |
Last Modified: | 02 Sep 2019 09:42 |
Status: | Published |
Publisher: | Springer Nature |
Identification Number: | 10.1038/s41370-018-0056-7 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:141773 |