Kamada, Katsuhiko and Barilla, Daniela orcid.org/0000-0002-3486-7492 (2018) Combing Chromosomal DNA Mediated by the SMC Complex: Structure and Mechanisms. Bioessays. ISSN 0265-9247
Abstract
Genome maintenance requires various nucleoid‐associated factors in prokaryotes. Among them, the SMC (Structural Maintenance of Chromosomes) protein has been thought to play a static role in the organization and segregation of the chromosome during cell division. However, recent studies have shown that the bacterial SMC is required to align left and right arms of the emerging chromosome and that the protein dynamically travels from origin to Ter region. A rod form of the SMC complex mediates DNA bridging and has been recognized as a machinery responsible for DNA loop extrusion, like eukaryotic condensin or cohesin complexes, which act as chromosome organizers. Attention is now turning to how the prototype of the complex is loaded on the entry site and translocated on chromosomal DNA, explaining its overall conformational changes at atomic levels. Here, we review and highlight recent findings concerning the prokaryotic SMC complex and discuss possible mechanisms from the viewpoint of protein architecture.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 24 Jan 2019 17:00 |
Last Modified: | 21 Jan 2025 17:37 |
Published Version: | https://doi.org/10.1002/bies.201700166 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/bies.201700166 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:141601 |
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