Koufakis, T, Antonopoulou, V, Grammatiki, M et al. (4 more authors) (2018) The relationship between primary hyperparathyroidism and thrombotic events: Report of three cases and a review of potential mechanisms. International Journal of Hematology-Oncology and Stem Cell Research, 12 (3). pp. 174-179. ISSN 1735-1243
Abstract
We have described three uncommon cases of patients who presented with clinical thrombotic events (stroke, pulmonary embolism and deep venous thrombosis) during the course of a hypercalcemia-induced hypercoagulable state. After thorough investigation, the diagnosis of primary hyperparathyroidism - due to a parathyroid adenoma - was established in all cases. The association between hypercalcemia and venous or arterial thrombosis has been previously described; however, relevant data are still insufficient. The existing evidence in the field was reviewed and the interesting underlying pathophysiologic mechanisms were also discussed. Further studies are required to shed more light on the unusual, still intriguing relationship between calcium and thrombosis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
Keywords: | Calcium; Primary hyperparathyroidism; Thrombosis; Stroke; Pulmonary embolism; Deep venous thrombosis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Clinical & Population Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Jan 2019 15:43 |
Last Modified: | 12 May 2019 21:11 |
Published Version: | http://ijhoscr.tums.ac.ir/index.php/ijhoscr/articl... |
Status: | Published |
Publisher: | Tehran University of Medical Sciences |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:141599 |