Howell, D, Smith, A, Appleton, S et al. (5 more authors) (2017) Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study. British Journal of Haematology, 177 (1). pp. 67-71. ISSN 0007-1048
Abstract
Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012–2013 using data from our population‐based patient cohort that links to national death notifications and collects details on treatment and response (n = 441). Emergency presentation was associated with advanced disease and poorer outcomes, and was the commonest route to diagnosis (28·1%) followed by General Practitioner urgent (19·0%) and two‐week wait (17·2%) referrals. CRAB (elevated Calcium, Renal failure, Anaemia, Bone lesions) distribution varied by route (P < 0·001), with patients with emergency presentations most likely to have ≥2 features and significantly worse survival (log‐rank test χ2 = 13·8, P = 0·0002).
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd. British Journal of Haematology, This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in anymedium, provided the original work is properly cited. A copy of the license can be found at: https://creativecommons.org/licenses/by/4.0/ |
Keywords: | multiple myeloma; route to diagnosis; clinical characteristics; survival; emergency presentation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Oncology and Clinical Research (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Jan 2019 12:45 |
Last Modified: | 24 Jan 2019 12:52 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/bjh.14513 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:141462 |