The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases

Abstract

Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important vertebrate model to study these processes. Key mechanisms such as DNA damage responses and cellular senescence can be studied in zebrafish throughout its life course. In addition, the zebrafish is becoming an important resource to study telomere biology in aging, regeneration and cancer. Here we review some of the tools and resources that zebrafish researchers have developed and discuss their potential use in the study of DNA damage, cancer and aging related diseases.

Metadata

Item Type:	Article
Authors/Creators:	Cayuela, M.L. B.M. Klaes, K. Godinho Ferreira, M. Henriques, C.M. https://orcid.org/0000-0003-1882-756X Van Eeden, F. Varga, M. Vierstraete, J. Mione, M.C.
Copyright, Publisher and Additional Information:	© 2019 Cayuela, Claes, Ferreira, Henriques, van Eeden, Varga, Vierstraete and Mione. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords:	Zebrafish; DDR; aging; telomeres; cancer; genome maintenance; disease model; p53
Dates:	Published: 10 January 2019 Published (online): 10 January 2019 Accepted: 22 December 2018
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield)
Funding Information:	Funder Grant number WELLCOME TRUST (THE) 206224/Z/17/Z
Depositing User:	Symplectic Sheffield
Date Deposited:	18 Feb 2019 14:04
Last Modified:	18 Feb 2019 14:04
Published Version:	https://doi.org/10.3389/fcell.2018.00178
Status:	Published
Publisher:	Frontiers Media
Refereed:	Yes
Identification Number:	10.3389/fcell.2018.00178
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:141426

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The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases

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