Khorsheed, B. orcid.org/0000-0001-6337-4841, Gabbott, I., Reynolds, G.K. et al. (3 more authors) (2019) Twin-screw granulation: Understanding the mechanical properties from powder to tablets. Powder Technology, 341. pp. 104-115. ISSN 0032-5910
Abstract
Granulation is a technique commonly used before tabletting because it solves powder handling problems and ensures uniform filling of the compression dies. However, granulation can have an adverse impact on powder transformation into a tablet; i.e. tabletability.
The aim of this work is to examine the effect of continuous wet granulation using twin-screw granulator (TSG) on the tabletability of the granulated materials. Also, the study investigates the mechanisms that dictate the change in tabletability after wet granulation using TSG.
Granules and tablet properties were characterised using a range of mechanical and X-ray analysis techniques. It was found that wet granulation using TSG has an impact on the tabletability of the granulated pharmaceutical excipients. The presented work suggests that there is a correlation between the yield pressure, plastic and elastic work of the primary powder and the percentage of change in tabletability after granulation. The study found that plastically deformable materials like microcrystalline cellulose (MCC) experience a significant reduction of tabletability (up to 67%) when granulated compared with the direct compression of its powder. On the other hand, brittle materials like crystalline mannitol C160 or calcium phosphate dibasic anhydrous maintain their tabletability after twin-screw granulation.
The presented results show that the granule size of microcrystalline cellulose and mannitol 100 SD does not affect tabletability for the range studied. However increasing the strength of granules was found to cause reduction of the tabletability. On the other hand, the granule size of mannitol C160 and calcium phosphate dibasic anhydrous did affect its tabletability.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Elsevier. |
Keywords: | Twin-screw granulation; Tabletability; Compactability; Mechanical properties; Reduction of tabletability; Work of compaction; Plastic work; Elastic work |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 21 Jan 2019 15:02 |
Last Modified: | 21 Jan 2019 15:05 |
Published Version: | https://doi.org/10.1016/j.powtec.2018.05.013 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.powtec.2018.05.013 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:141411 |