Kumar, V orcid.org/0000-0002-8825-3517, Yadav, N and Kartha, KPR (2016) Synthetic multivalent ligands for cholera & cholera-like toxins: Protected cyclic neoglycopeptides. Carbohydrate Research, 431. pp. 47-55. ISSN 0008-6215
Abstract
Synthesis of a set of novel glycopeptide analogues as potential cholera/cholera-like toxin inhibitors in their protected form is described. They include di-, tri-, tetra- and pentavalent scaffolds. The synthetic steps were achieved using a combination of solvent-free mechanochemical as well as the conventional solution-phase reactions. During the conventional DIC-HOBt-mediated peptide coupling followed for the preparation of certain glycopeptide analogues an interesting in situ Fmoc deprotection was observed which has been demonstrated to hold potential for synthesiszing glycopeptides/neoglycopeptides with extended polyamide chains.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Glycoconjugates; Neoglycopeptides; Diarrhoea; Cholera toxin; Multivalent inhibitors |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Jan 2019 15:37 |
Last Modified: | 22 Jan 2019 09:44 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.carres.2016.05.011 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:141275 |