Kumar, V orcid.org/0000-0002-8825-3517 (2017) Cross-linked galactosides as potential ligands for cholera and cholera like toxins: Docking studies and self-assembling properties. Trends in Carbohydrate Research, 9 (3). pp. 54-62.
Abstract
© 2008 TrendsCarbo.com. D-Galactose-based divalent neoglycopeptides synthesized as potential ligands for cholera toxin were subjected to molecular docking studies to enable prediction of their inhibitory potential. These cross-linked galactosides, namely, PAPGal- Glu-C10DA-Glu-PAPGal, PAPGal-Lys-C12-Lys-PAPGal, PAPGal-Ala-C12-Ala-PAPGal showed docking scores of -8.152, - 6.086 and -5.755, respectively, compared to a score of -5.522 for PAP-B-Gal and -5.732 for PAP-A-Gal, known galactoside ligands. Although it may not be desirable under the physiological conditions if prevailed, these compounds were also found to possess certain self-assembling properties in solution as were confirmed by TEM analysis of the structures so formed.
Metadata
Item Type: | Article |
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Authors/Creators: | |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Jan 2019 10:12 |
Last Modified: | 22 Jan 2019 10:13 |
Status: | Published |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:141274 |