Mesenchymal stromal cells for acute graft-versus-host disease: response at 1 week predicts probability of survival.

Abstract

Mesenchymal stromal cells (MSCs) have been successfully used for the treatment of steroid-resistant graft-versus-host-disease (GvHD). However, the lack of early predictors of clinical responses impacts on the time at which to add further treatment and consequently the design of informative clinical trials. Here, we present the UK experience of one of the largest cohorts of GvHD patients undergoing MSC infusions so far reported. We show that clinical responses assessed as early as 1 week after MSC infusion predict patients' overall survival. In our cohort, cell dose, patients' age and type of organ involvement are crucial factors associated with clinical responses.

Metadata

Item Type:	Article
Authors/Creators:	Galleu, A. Milojkovic, D. Deplano, S. Szydlo, R. Loaiza, S. Wynn, R. Marks, D.I. Richardson, D. Orchard, K. Kanfer, E. Tholouli, E. Saif, M. Sivaprakasam, P. Lawson, S. Bloor, A. Pagliuca, A. Potter, V. Mehra, V. https://orcid.org/0000-0001-6572-0971 Snowden, J.A. https://orcid.org/0000-0001-6819-3476 Vora, A. Kishore, B. Hunter, H. Apperley, J.F. Dazzi, F. https://orcid.org/0000-0003-2407-236X
Copyright, Publisher and Additional Information:	© 2019 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Keywords:	GvHD; cellular therapies; clinical research; mesenchymal cells; stromal cells
Dates:	Accepted: 11 December 2018 Published (online): 13 January 2019 Published: 25 March 2019
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Sheffield Teaching Hospitals
Depositing User:	Symplectic Sheffield
Date Deposited:	11 Mar 2019 10:37
Last Modified:	16 Nov 2021 09:57
Status:	Published
Publisher:	Wiley
Refereed:	Yes
Identification Number:	10.1111/bjh.15749
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:141257

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Mesenchymal stromal cells for acute graft-versus-host disease: response at 1 week predicts probability of survival.

Abstract

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