Sharma, D, Patel, RP, Zaidi, STR orcid.org/0000-0002-2031-1055 et al. (3 more authors) (2017) Interplay of the Quality of Ciprofloxacin and Antibiotic Resistance in Developing Countries. Frontiers in Pharmacology, 8. 546. ISSN 1663-9812
Abstract
Ciprofloxacin, a second generation broad spectrum fluoroquinolone, is active against both Gram-positive and Gram-negative bacteria. Ciprofloxacin has a high oral bioavailability and a large volume of distribution. It is used for the treatment of a wide range of infections including urinary tract infections caused by susceptible bacteria. However, the availability and use of substandard and spurious quality of oral ciprofloxacin formulations in the developing countries has been thought to have contributed toward increased risk of treatment failure and bacterial resistance. Therefore, quality control and bioequivalence studies of the commercially available oral ciprofloxacin formulations should be monitored. Appropriate actions should be taken against offending manufacturers in order to prevent the sale of substandard and spurious quality of ciprofloxacin formulations.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Sharma, Patel, Zaidi, Sarker, Lean and Ming. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Keywords: | antibiotic resistance, ciprofloxacin, quality assurance, substandard drug, spurious drug, pharmacovigilence and drug monitoring, drug regulatory system, fluoroquinolones |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Healthcare (Leeds) > Pharmacy (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Jan 2019 15:23 |
Last Modified: | 28 Mar 2019 15:28 |
Status: | Published |
Publisher: | Frontiers Media |
Identification Number: | 10.3389/fphar.2017.00546 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:141230 |