Cohen, N orcid.org/0000-0002-1633-3315 and Denham, JE (2019) Whole animal modeling: piecing together nematode locomotion. Current Opinion in Systems Biology, 13. pp. 150-160. ISSN 2452-3100
Abstract
With a reconstructed and extensively characterized neural circuit, Caenorhabditis elegans is a fascinating model system for the study of neural circuits and behavior. Here, we review recent progress in the study of locomotion in this animal from a systems perspective. We discuss how complementary approaches, from network science, through dynamical systems to biomechanics are transforming the current understanding of this system into a unified whole animal description. This transformation has been achieved through the integration of mechanistic studies and decompositional approaches: on the one hand, mapping the components of the system and their functions and on the other hand, providing qualitative and quantitative methods to probe the physical basis of locomotion, motor behavior, neural dynamics, and structure–function relation in neural circuits.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Funding Information: | Funder Grant number EPSRC EP/J004057/1 EPSRC EP/S01540X/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Jan 2019 15:42 |
Last Modified: | 15 Feb 2019 12:26 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.coisb.2018.12.002 |
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Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:140906 |