Schoon, J., Wood, S. and Brown, J. (2018) TKIs in renal cell carcinoma: What can we expect in the future? In: Dammacco, F. and Silvestris, F., (eds.) Oncogenomics: From Basic Research to Precision Medicine. Academic Press , pp. 551-563. ISBN 9780128117859
Abstract
Kidney cancer represents 5% of all new cancer diagnoses and is commonly associated with the loss of function of the von Hippel–Lindau (VHL) tumor-suppressor protein and as a consequence aberrant signaling by tyrosine kinases. This observation has led to the use of tyrosine-kinase inhibitors (TKIs) as targeted therapies revolutionizing the treatment of metastatic kidney cancer and improving patient survival as both first-line and second-line therapies. Multiple clinical trials have established improved treatment strategies to maximize patient response. Despite these advances issues still remain regarding side-effects of TKI-treatment and biomarkers are required to predict which patients will derive maximum benefit from TKI-therapy, as well as to monitor drug response. Resistance to TKI-therapy occurs upon prolonged treatment and recent studies have investigated the combination of TKIs with newer immunotherapies to improve patient response. This review discusses clinically approved TKIs, current TKI-based clinical trials and potential future drug-combinations for use in treatment.
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © 2019 Elsevier. |
Keywords: | Tyrosine-kinase-inhibitors; renal cell carcinoma; biomarkers; adjuvant; metastatic |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 03 May 2019 10:48 |
Last Modified: | 03 May 2019 10:52 |
Status: | Published |
Publisher: | Academic Press |
Refereed: | Yes |
Identification Number: | 10.1016/B978-0-12-811785-9.00039-9 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:140442 |