Idkowiak, J., Elhassan, Y.S., Mannion, P. et al. (13 more authors) (2019) Causes, patterns and severity of androgen excess in 487 consecutively recruited pre- and post-pubertal children. European Journal of Endocrinology, 180 (3). pp. 213-221. ISSN 0804-4643
Abstract
OBJECTIVE: Androgen excess in childhood is a common presentation and may signify sinister underlying pathology. Data describing its patterns and severity are scarce, limiting the information available for clinical decision processes. Here, we examined the differential diagnostic value of serum dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), and testosterone (T) in childhood androgen excess. DESIGN: Retrospective review of all children undergoing serum androgen measurement at a single center over 5 years. METHODS: Serum A4 and T were measured by tandem mass spectrometry, DHEAS by immunoassay. Patients with at least one increased androgen underwent phenotyping by clinical notes review. RESULTS: In 487 children with simultaneous DHEAS, A4, and T measurements, we identified 199 with androgen excess (140 pre- and 59 post-pubertal). Premature adrenarche (PA) was the most common pre-pubertal diagnosis (61%), characterized by DHEAS excess in 85%, while A4 and T were only increased in 26% and 9%, respectively. PCOS was diagnosed in 40% of post-pubertal subjects, presenting equally frequent with isolated excess of DHEAS (29%) or T (25%) or increases in both A4 and T (25%). CAH patients (6%) predominantly had A4 excess (86%); T and DHEAS were increased in 50% and 33%, respectively. Concentrations increased above the two-fold upper limit of normal were mostly observed in PA for serum DHEAS (>20fold in the single case of adrenocortical carcinoma), and in CAH for serum androstenedione. CONCLUSIONS: Patterns and severity of childhood androgen excess provides pointers to the underlying diagnosis and can be used to guide further investigations.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The authors. This is an author-produced version of a paper accepted for publication in European Journal of Endocrinology. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Oncology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Jan 2019 11:01 |
Last Modified: | 24 Nov 2021 14:40 |
Status: | Published |
Publisher: | BioScientifica |
Refereed: | Yes |
Identification Number: | 10.1530/EJE-18-0854 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:140386 |