Stockdale, Lisa, Nash, Stephen, Nalwoga, Angela et al. (6 more authors) (2019) HIV, HCMV and mycobacterial antibody levels:a cross-sectional study in a rural Ugandan cohort. Tropical Medicine and International Health. pp. 247-257. ISSN 1365-3156
Abstract
Objectives:A growing evidence base implicates human cytomegalovirus (HCMV) as a risk factor for TB disease. We investigated total IgG and mycobacteria-specific antibodies in a cross-sectional study nested within a rural Ugandan General Population Cohort (GPC), in relation to HIV infection and the magnitude of HCMV IgG response. Methods: Sera from 2,189 individuals (including 27 sputum-positive TB cases) were analysed for antibodies against mycobacteria (Ag85A, PPD, LAM, ESAT6/CFP10) and HCMV, tetanus toxoid (TT) and total IgG. Accepted Article This article is protected by copyright. All rights reserved. Results: Anti-mycobacterial antibodies increased with age until approximately 20 years, when they plateaued. Higher HCMV exposure (measured by IgG) was associated with lower levels of some anti-mycobacterial antibodies, but no increase in total IgG. HIV infection was associated with a decrease in all anti-mycobacterial antibodies measured and with an increase in total IgG. Conclusions: The increase in anti-mycobacterial antibodies with age suggests increasing exposure to non-tuberculous mycobacteria (NTM), and to M.tb itself. HIV infection is associated with decreased levels of all mycobacterial antibodies studied here, and high levels of HCMV IgG are associated with decreased levels of some mycobacterial antibodies. These findings point towards the importance of humoral immune responses in HIV/TB co-infection and highlight a possible role of HCMV as a risk factor for TB disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Authors. Tropical Medicine & International Health Published by John Wiley & Sons Ltd. |
Keywords: | HCMV,HIV,Mycobacterium,TB,Immunoglobulin G/blood,Cytomegalovirus/immunology,Humans,Middle Aged,Child, Preschool,Nontuberculous Mycobacteria/immunology,Infant,Male,Young Adult,Rural Population,Sputum/microbiology,Aged, 80 and over,Adult,Cytomegalovirus Infections/complications,Female,Child,Tuberculosis/epidemiology,Antibodies, Viral/blood,Cross-Sectional Studies,Mycobacterium tuberculosis/immunology,Uganda/epidemiology,Linear Models,HIV Infections/complications,Adolescent,Aged,Cohort Studies |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 18 Dec 2018 12:40 |
Last Modified: | 16 Oct 2024 15:20 |
Published Version: | https://doi.org/10.1111/tmi.13188 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1111/tmi.13188 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:140124 |
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