Mao, Z, Chong, J orcid.org/0000-0002-5846-7397 and Ong, ACM (2016) Autosomal dominant polycystic kidney disease: recent advances in clinical management. F1000Research, 5. 2029. ISSN 2046-1402
Abstract
The first clinical descriptions of autosomal dominant polycystic kidney disease (ADPKD) go back at least 500 years to the late 16th century. Advances in understanding disease presentation and pathophysiology have mirrored the progress of clinical medicine in anatomy, pathology, physiology, cell biology, and genetics. The identification of PKD1 and PKD2, the major genes mutated in ADPKD, has stimulated major advances, which in turn have led to the first approved drug for this disorder and a fresh reassessment of patient management in the 21st century. In this commentary, we consider how clinical management is likely to change in the coming decade.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2016 Mao Z et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | autosomal dominant polycystic kidney disease, ADPKD, PDK1, PDK2, clinical management |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Infection and Immunity (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Dec 2018 11:38 |
Last Modified: | 18 Dec 2018 11:38 |
Status: | Published |
Publisher: | F1000Research |
Identification Number: | 10.12688/f1000research.9045.1 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:140032 |
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