Skelly, J, Pushparajan, C, Duncan, EJ orcid.org/0000-0002-1841-504X et al. (1 more author) (2019) Evolution of the Torso activation cassette, a pathway required for terminal patterning and moulting. Insect Molecular Biology, 28 (3). pp. 392-408. ISSN 0962-1075
Abstract
Embryonic terminal patterning and moulting are critical developmental processes in insects. In Drosophila and Tribolium both of these processes are regulated by the Torso‐activation cassette (TAC). The TAC consists of a common receptor, Torso, ligands Trunk and prothoracicotropic hormone (PTTH), and the spatially restricted protein Torso‐like, with combinations of these elements acting mechanistically to activate the receptor in different developmental contexts. In order to trace the evolutionary history of the TAC we determined the presence or absence of TAC components in the genomes of arthropods. Our analyses reveal that Torso, Trunk and PTTH are evolutionarily labile components of the TAC with multiple individual or combined losses occurring in the arthropod lineages leading to and within the insects. These losses are often correlated, with both ligands and receptor missing from the genome of the same species. We determine that the PTTH gene evolved in the common ancestor of Hemiptera and Holometabola, and is missing from the genomes of a number of species with experimentally demonstrated PTTH activity, implying another molecule may be involved in ecdysis in these species. In contrast, the torso‐like gene is a common component of pancrustacean genomes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018, The Royal Entomological Society. All rights reserved. This is the peer reviewed version of the following article: Skelly, J, Pushparajan, C, Duncan, EJ et al. (1 more author) (2018) Evolution of the Torso activation cassette, a pathway required for terminal patterning and moulting. Insect Molecular Biology , which has been published in final form at http://dx.doi.org/10.1111/imb.12560. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. (https://authorservices.wiley.com/author-resources/Journal-Authors/licensing-open-access/open-access/self-archiving.html) |
Keywords: | terminal patterning; ecdysis; genome evolution; moulting |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Dec 2018 13:37 |
Last Modified: | 12 Dec 2019 01:39 |
Status: | Published |
Publisher: | Blackwell Publishing Inc. |
Identification Number: | 10.1111/imb.12560 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:139927 |