Shapiro, S. and Makris, M. orcid.org/0000-0001-7622-7939 (2019) Haemophilia and ageing. British Journal of Haematology, 184 (5). pp. 712-720. ISSN 0007-1048
Abstract
Advances in the development of effective and safe treatments for haemophilia over the last 50 years have resulted in a significant increase in the life expectancy of persons with haemophilia (PWH). The management of this new cohort of middle‐aged and elderly PWH is challenging because of the opposing risks of haemophilia and age‐related cardiovascular disease and malignancy. Furthermore, this cohort of ageing PWH has the additional comorbidities of human immunodeficiency virus/hepatitis C and chronic haemophilic arthropathy. This article reviews the prevalence, underlying mechanisms and treatment strategies for managing these comorbidities. International collaboration is essential for registry data and further prospective trials to inform optimal evidence‐based management for this rare disorder in the future.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 British Society for Haematology and John Wiley & Sons Ltd. This is an author produced version of a paper subsequently published in British Journal of Haematology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Haemophilia; ageing; comorbidity; cardiovascular; musculoskeletal |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Dec 2018 10:03 |
Last Modified: | 24 Nov 2021 10:42 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/bjh.15745 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:139926 |