Zhao, Jianxiong, Lichman, Benjamin R. orcid.org/0000-0002-0033-1120, Ward, John M. et al. (1 more author) (2018) One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues. Chemical Communications. pp. 1323-1326. ISSN 1364-548X
Abstract
Chemoenzymatic reaction cascades can provide access to chiral compounds from low-cost starting materials in one pot. Here we describe one-pot asymmetric routes to tetrahydroisoquinoline alkaloids (THIAs) using the Pictet-Spenglerase norcoclaurine synthase (NCS) followed by a cyclisation, to give alkaloids with two new heterocyclic rings. These reactions operated with a high atom economy to generate THIAs in high yields.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | ©The Royal Society of Chemistry 2018 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 06 Dec 2018 12:00 |
Last Modified: | 23 Jan 2025 00:17 |
Published Version: | https://doi.org/10.1039/c7cc08024g |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/c7cc08024g |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:139667 |