Dunneram, Y orcid.org/0000-0002-1012-7350, Greenwood, D orcid.org/0000-0001-7035-3096 and Cade, JE orcid.org/0000-0003-3421-0121 (2019) Diet and risk of breast, endometrial and ovarian cancer: UK Women’s Cohort Study. British Journal of Nutrition, 122 (5). pp. 564-574. ISSN 0007-1145
Abstract
This study aimed to investigate associations between diet and the risk of breast, endometrial and ovarian cancer in the UK Women’s Cohort Study. 35,372 women aged 35-69 years were enrolled between 1995 and 1998 and completed a validated 217-item food frequency questionnaire. The individual foods were collapsed into 64 main food groups, compared using Cox proportional models, adjusting for potential confounders. Hazard ratio (HR) estimates are presented per portion increase of food items. After approximately 18 years of follow-up, there were 1822, 294, and 285 cases of breast, endometrial and ovarian cancer respectively. A high consumption of processed meat and total meat was associated with an increased risk of breast and endometrial cancer. High intakes of tomatoes (HR: 0.87, 99% confidence interval (CI): 0.75 to 1.00) and dried fruits (HR: 0.60, 99% CI: 0.37 to 0.97) were associated with a reduced risk of breast and endometrial cancer respectively. Mushroom intake was associated with a higher risk of ovarian cancer (HR 1.57, 99% CI: 1.09 to 2.26). Subgroup analysis by pre or post-menopausal cancer further demonstrated an association between processed meat intake and both postmenopausal breast cancer and endometrial cancer. Dried fruits intake was associated with a reduced risk of postmenopausal endometrial cancer (HR: 0.55, 99% CI: 0.31 to 0.98). Our findings suggest that while some foods may trigger the risk of these cancers, some foods may also be protective; supporting the call for further randomised controlled trials of dietary interventions to reduce risk of cancer among pre and postmenopausal women.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Authors 2019. This article has been published in a revised form in the British Journal of Nutrition. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | diet; food groups; breast cancer; endometrial cancer; ovarian cancer; premenopausal women; postmenopausal women; hazard ratio; hormone replacement therapy; International Classification of Diseases; UK Women's Cohort Study |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Nutrition and Public Health (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Clinical & Population Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Nov 2018 15:32 |
Last Modified: | 23 Oct 2019 15:22 |
Status: | Published |
Publisher: | Cambridge University Press |
Identification Number: | 10.1017/S0007114518003665 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:139250 |