Ariëns, RAS orcid.org/0000-0002-6310-5745 (2016) Novel mechanisms that regulate clot structure/function. Thrombosis Research, 141. S2. S25-S27. ISSN 0049-3848
Abstract
The structure and function of the blood clot has been associated with altered risk of thrombosis. Dense fibrin structures with small pores increase the risk of thrombosis, and have major functional consequences by increasing the resistance to fibrinolysis and altering the visco-elastic properties of the clot. However, while the structural changes to the overall fibrin network have been extensively characterised, little is known regarding the intrafibrillar structure of fibrin, the way protofibrils are arranged inside the fibrin fibers and the functional consequences of this. This brief paper aims to review recent findings regarding novel mechanisms that regulate fibrin intrafibrillar structure, including the degree of protofibril packing, their functional consequences, and the effects of FXIII activation on clot structure and thrombosis. It is concluded that fibrin intrafibrillar structure represents a major novel mechanism that influences clot structure and stability. Future studies are required to investigate the role of fibrin intrafibrillar structure in the functional characteristics of the blood clot, and in diseases of bleeding and thrombosis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | fibrinogen; fibrin; FXIII; Thrombin; clot structure; intrafibrillar structure |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Nov 2018 16:39 |
Last Modified: | 01 Feb 2019 11:57 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/S0049-3848(16)30358-9 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:138876 |