Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017

Abstract

Objective: To assess the uptake of the OMERACT-OARSI (Outcome Measures in Rheumatology- Osteoarthritis Research Society International) core outcome set (COS) domains in hip and/or knee osteoarthritis (OA) trials.

Methods: There were 382 trials of hip and/or knee OA identified from the ClinicalTrial.gov registry from 1997 to 2017. Frequency of COS adoption was assessed by year and per 5-yearly phases.

Results: COS adoption decreased from 61% between 1997 and 2001 to 38% between 2012 and 2016. Pain (95%) and physical function (86%) were most consistently adopted. Patient’s global assessment (48%) was the principal missing domain.

Conclusion: Limited adoption of the COS domains indicates that further consideration to improve uptake is required.

Metadata

Item Type:	Article
Authors/Creators:	Smith, TO Mansfield, M Hawker, GA Hunter, DJ March, LM Boers, M Shea, BJ Christensen, R Guillemin, F Terwee, CB Williamson, PR Roos, EM Loeser, RF Schnitzer, TJ Kloppenburg, M Neogi, T Ladel, CH Kalsi, G Kaiser, U Buttel, TW Ashford, AE Mobasheri, A Arden, NK Tennant, A Hochberg, MC De Wit, M Tugwell, PS Conaghan, PG https://orcid.org/0000-0002-3478-5665
Copyright, Publisher and Additional Information:	© 2019 The Journal of Rheumatology. This is a pre-copyediting, author-produced PDF of an article accepted for publication in The Journal of Rheumatology following peer review. The definitive publisher-authenticated version Smith, TO, Mansfield, M, Hawker, GA et al. 2019 Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017. Journal of Rheumatology. ISSN 0315-162X is available online at: https://doi.org/10.3899/jrheum.181066
Keywords:	OMERACT; CORE OUTCOME SET; DOMAIN; ADOPTION; TRIAL REGISTRATION
Dates:	Published: 1 August 2019 Published (online): 1 March 2019 Accepted: 15 November 2018
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Musculoskeletal Medicine & Imaging (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	19 Nov 2018 14:34
Last Modified:	01 Mar 2020 01:38
Status:	Published
Publisher:	Journal of Rheumatology
Identification Number:	10.3899/jrheum.181066
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:138754

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Uptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017

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