Lord, R, Zegke, M, Henderson, IR et al. (3 more authors) (2019) β‐Ketoiminato iridium(III) organometallic complexes: Selective cytotoxicity towards colorectal cancer cells HCT116 p53‐/‐. Chemistry - A European Journal, 25 (2). pp. 495-500. ISSN 0947-6539
Abstract
This report presents a new library of organometallic iridium(III) compounds of the type [Cp*IrCl(N,O)] (Cp* = pentamethylcyclopentadienyl and N,O = a functionalized β‐ketoiminato ligand) showing moderate to high cytotoxicity against a range of cancer cell lines. All compounds show increased activity towards colorectal cancer, with preferential activity observed against the immortalized p53‐null colorectal cell line, HCT116 p53‐/‐, with sensitivity factors (SF) up to 26.7. Additionally, the compounds have excellent selectivity for cancerous cells when tested against normal cell types, with selectivity ratios (SR) up to 35.6, contrary to that of cisplatin which is neither selective nor specific for cancerous cells (SF = 0.43 and SR = 0.7‐2.3). This work provides a preliminary understanding of the cytotoxicity of iridium compounds in the absence of p53 and has potential applications in treatment of cancers for which the p53 gene is absent or mutant.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Lord, R. , Zegke, M. , Henderson, I. ., Pask, C. ., Shepherd, H. . and McGowan, P. . (2018), β‐Ketoiminato iridium(III) organometallic complexes: Selective cytotoxicity towards colorectal cancer cells HCT116 p53‐/‐. Chem. Eur. J.. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/chem.201804901. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bioinorganic chemistry; cancer; colorectal cancer; iridium; organometallic |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Inorganic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Nov 2018 14:15 |
Last Modified: | 25 Oct 2019 00:39 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/chem.201804901 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:138615 |