Chinen, T, Kannan, AK, Levine, AG et al. (7 more authors) (2016) An essential role for the IL-2 receptor in Treg cell function. Nature Immunology, 17 (11). pp. 1322-1333. ISSN 1529-2908
Abstract
Regulatory T cells (Treg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by Treg cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the Treg cell lineage–specification factor Foxp3, which has confounded experimental efforts to understand the role of IL-2R expression and signaling in the suppressor function of Treg cells. Using genetic gain- and loss-of-function approaches, we found that capture of IL-2 was dispensable for the control of CD4+ T cells but was important for limiting the activation of CD8+ T cells, and that IL-2R-dependent activation of the transcription factor STAT5 had an essential role in the suppressor function of Treg cells separable from signaling via the T cell antigen receptor.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2016 Nature America, Inc. All rights reserved. This is an author produced manuscript of an article published in Nature Immunology. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Experimental Haematology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Nov 2018 14:56 |
Last Modified: | 06 Nov 2018 14:56 |
Status: | Published |
Publisher: | Springer Nature |
Identification Number: | 10.1038/ni.3540 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:138153 |