Mazuela, J, Antonsson, T, Knerr, L et al. (3 more authors) (2019) Iridium‐Catalyzed Asymmetric Hydrogenation of N‐Alkyl α‐Aryl Furan‐Containing Imines: an Efficient Route to Unnatural N‐Alkyl Arylalanines and Related Derivatives. Advanced Synthesis and Catalysis, 361 (3). pp. 578-584. ISSN 1615-4150
Abstract
High throughput experimentation (HTE) has enabled the rapid identification of ligand/precatalyst combinations that facilitate highly enantioselective hydrogenations of prochiral N‐alkyl α‐aryl ketimines containing a furyl moiety. The chiral amines obtained have proven to be modular precursors in the synthesis of novel unnatural mono N‐alkylated arylalanines and related derivatives.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Mazuela, J, Antonsson, T, Knerr, L et al. (3 more authors) (2018) Iridium‐Catalyzed Asymmetric Hydrogenation of N‐Alkyl α‐Aryl Furan‐Containing Imines: an Efficient Route to Unnatural N‐Alkyl Arylalanines and Related Derivatives. Advanced Synthesis and Catalysis, which has been published in final form at https://doi.org/10.1002/adsc.201801143. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | arylalanines; unnatural N-alkyl amino acids; Iridium; asymmetric hydrogenation; high throughput experimentation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Nov 2018 12:09 |
Last Modified: | 29 Oct 2019 01:38 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/adsc.201801143 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:138122 |