Summerfield, DT, Coffman, KE, Taylor, BJ orcid.org/0000-0001-5229-941X et al. (2 more authors) (2018) Exhaled Nitric Oxide Changes During Acclimatization to High Altitude: A Descriptive Study. High Altitude Medicine and Biology, 19 (3). pp. 215-220. ISSN 1527-0297
Abstract
Aims: This study describes differences in the partial pressures of exhaled nitric oxide (PeNO) between subjects fully acclimatized (ACC) to 5300 m and those who have just arrived to high altitude.
Methods: PeNO was determined in eight subjects newly exposed and nonacclimatized (non-ACC) to high altitude and compared with that in nine subjects who had ACC to high altitude for 1 month. In addition, systolic pulmonary artery pressure (sPAP) and arterial oxygen saturation (SaO₂) were measured in all participants. These measurements were repeated in the non-ACC group 5 and 9 days later.
Results: PeNO levels on day 1 were significantly higher in the non-ACC versus ACC cohort (8.7 ± 3.5 vs. 3.9 ± 2.2 nmHg, p = 0.004). As the non-ACC group remained at altitude, PeNO levels fell and were not different when compared with those of the ACC group by day 9 (5.9 ± 2.4 vs. 3.9 ± 2.2 nmHg, p = 0.095). Higher sPAP was correlated with lower PeNO levels in all participants (R = −0.50, p = 0.043). PeNO levels were not correlated with SaO₂.
Conclusions: As individuals acclimatized to high altitude, PeNO levels decreased. Even after acclimatization, PeNO levels continued to play a role in pulmonary vascular tone.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) Mary Ann Liebert, Inc. This is an author produced version of a paper published in High Altitude Medicine and Biology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | acclimatization; exhaled nitric oxide; high altitude populations; systolic pulmonary artery pressure |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 05 Nov 2018 15:12 |
Last Modified: | 14 May 2019 00:40 |
Status: | Published |
Publisher: | Mary Ann Liebert Inc. |
Identification Number: | 10.1089/ham.2017.0109 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:138033 |