Bonakdar, T and Ghadiri, M orcid.org/0000-0003-0479-2845 (2018) Analysis of pin milling of pharmaceutical materials. International Journal of Pharmaceutics, 552 (1-2). pp. 394-400. ISSN 0378-5173
Abstract
Milling is an important process for tailoring the particle size distribution for enhanced dissolution, content uniformity, tableting, etc., specially for active pharmaceutical ingredients and excipient in pharmaceutical industries. Milling performance of particulate solids depends on the equipment operating conditions (geometry, process conditions and input energy etc.) as well as material properties (particle size, shape, and mechanical properties, such as Young’s modulus, hardness and fracture toughness). In this work, a newly developed approach to assess the breakability of pharmaceutical materials using an aerodynamic dispersion method has been combined with the Discrete Element Method (DEM) to simulate the dynamic behaviour of a number of pharmaceutical materials in a pin mill. A sensitivity analysis is carried out addressing the effect of the milling conditions (rotational speed of the mill and feed particle flow rate) and feed properties on the milled products in terms of the shift in the specific surface area of the milled particles. The outcome of the work is used as a method to predict the breakage of the particles for the milling conditions where chipping takes place.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Elsevier B.V. This is an author produced version of a paper published in International Journal of Pharmaceutics. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Milling; Breakage; Impact; Picoline; Pin mill |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 Oct 2018 14:01 |
Last Modified: | 06 Oct 2019 00:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ijpharm.2018.09.068 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:137981 |
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