Handforth, C., D'Oronzo, S. and Brown, J. (2018) Medical Prevention and Treatment of Bone Metastases. In: Bilezikian, J.P., (ed.) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, , 9th Edition. Wiley-Blackwell , pp. 799-808. ISBN 978-1-119-26658-7
Abstract
The presence of metastatic bone disease is a devastating complication that has signiicant impact on morbidity and mortality in cancer patients. Although the type, incidence, and consequences of bone metastases (BM) may vary between primary cancer sites, all patients with BM require consideration as to how both their primary tumour and their bone disease should be managed in terms of avoiding complications and maximizing both quality of life and survival. This chapter will describe normal bone turnover, the pathophysiology of BM, and the most common clinical sequelae. We will then explain the current evidence for the prevention and treatment of BM for the most osteotropic tumours (breast, prostate, lung, and renal).
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Editors: |
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Copyright, Publisher and Additional Information: | © 2018 Wiley. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 07 Nov 2018 14:52 |
Last Modified: | 07 Nov 2018 14:52 |
Published Version: | https://www.wiley.com/en-gb/Primer+on+the+Metaboli... |
Status: | Published |
Publisher: | Wiley-Blackwell |
Refereed: | Yes |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:137824 |