Jones, EA orcid.org/0000-0001-9365-2283, Giannoudis, PV and Kouroupis, D (2016) Bone repair with skeletal stem cells: rationale, progress to date and clinical application. Therapeutic Advances in Musculoskeletal Disease, 8 (3). pp. 57-71. ISSN 1759-720X
Abstract
Bone marrow (BM) contains stem cells for both hematopoietic and nonhematopoietic lineages. Hematopoietic stem cells enable hematopoiesis to occur in a controlled manner in order to accurately compensate for the loss of short- as well as long-lived mature blood cells. The physiological role of nonhematopoietic BM stem cells, often referred to as multipotential stromal cells or skeletal stem cells (SSCs), is less understood. According to an authoritative current opinion, the main function of SSCs is to give rise to cartilage, bone, marrow fat and hematopoiesis-supportive stroma, in a specific sequence during embryonic and postnatal development. This review outlines recent advances in the understanding of origins and homeostatic functions of SSCs in vivo and highlights current and future SSC-based treatments for skeletal and joint disorders.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | bone repair; hematopoietic stem cells; multipotential stromal cells; osteoarthritis; skeletal stem cells; systemic bone diseases |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Orthopaedics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Oct 2018 12:57 |
Last Modified: | 23 Oct 2018 12:57 |
Status: | Published |
Publisher: | SAGE |
Identification Number: | 10.1177/1759720X16642372 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:137641 |