Pountos, I and Giannoudis, PV (2017) Effect of methotrexate on bone and wound healing. Expert Opinion on Drug Safety, 16 (5). pp. 535-545. ISSN 1474-0338
Abstract
Introduction: Methotrexate (MTX) is one of the most commonly used disease modifying drugs administered for wide spectrum of conditions. Through the expansion of the indications of MTX use, an increasing number of patients nowadays attend orthopaedic departments receiving this pharmacological agent. The aim of this manuscript is to present our current understanding on the effect of MTX on bone and wound healing.
Areas covered: The authors offer a comprehensive review of the existing literature on the experimental and clinical studies analysing the effect of MTX on bone and wound healing. The authors also analyse the available literature and describe the incidence of complications after elective orthopaedic surgery in patients receiving MTX.
Expert opinion: The available experimental data and clinical evidence are rather inadequate to allow any safe scientific conclusions on the effect of MTX on bone healing. Regarding wound healing, in vitro and experimental animal studies suggest that MTX can adversely affect wound healing, whilst the clinical studies show that lose-dose MTX is safe and does not affect the incidence of postoperative wound complications.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Keywords: | Methotrexate; mesenchymal stem cells; fibroblasts; osteoblasts; wound healing; bone healing; fracture |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Orthopaedics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 Oct 2018 14:48 |
Last Modified: | 22 Oct 2018 14:48 |
Status: | Published |
Publisher: | Taylor & Francis |
Identification Number: | 10.1080/14740338.2017.1310839 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:137551 |