mTOR Regulation of Glycolytic Metabolism in T Cells

Abstract

T cell activation, differentiation and effector function is intrinsically linked to the regulation of metabolic pathways. Evidence has shown that inflammatory T cell responses are dependent upon the adoption of aerobic glycolytic metabolism. Furthermore, activation and regulation of the mechanistic target of rapamycin signaling pathway serves a key determinant of T cell metabolism, with subsequent effects on T cell effector responses. In this mini-review, we discuss the mechanisms underpinning the function of the Warburg effect in T cell responses and the role of mTOR in these processes.

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Item Type:	Article
Authors/Creators:	Salmond, RJ https://orcid.org/0000-0002-1807-1056
Copyright, Publisher and Additional Information:	© 2018 Salmond. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	T cell; aerobic glycolysis; mTOR; metabolism; immune responses
Dates:	Accepted: 6 September 2018 Published (online): 25 September 2018 Published: 25 September 2018
Institution:	The University of Leeds
Funding Information:	Funder Grant number Cancer Research UK C55663/A23269
Depositing User:	Symplectic Publications
Date Deposited:	16 Oct 2018 10:46
Last Modified:	16 Oct 2018 10:46
Status:	Published
Publisher:	Frontiers Media
Identification Number:	10.3389/fcell.2018.00122
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:137145

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mTOR Regulation of Glycolytic Metabolism in T Cells

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