Krubitzer, L.A. and Prescott, T.J. orcid.org/0000-0003-4927-5390 (2018) The combinatorial creature: cortical phenotypes within and across lifetimes. Trends in Neurosciences, 41 (10). pp. 744-762. ISSN 0166-2236
Abstract
The neocortex is one of the most distinctive structures of the mammalian brain, yet also one of the most varied in terms of both size and organization. Multiple processes have contributed to this variability, including evolutionary mechanisms (i.e., alterations in gene sequence) that alter the size, organization, and connections of neocortex, and activity dependent mechanisms that can also modify these same features. Thus, changes to the neocortex can occur over different time-scales, including within a single generation. This combination of genetic and activity dependent mechanisms that create a given cortical phenotype allows the mammalian neocortex to rapidly and flexibly adjust to different body and environmental contexts, and in humans permits culture to impact brain construction.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | ©2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | neocortex; brain evolution; evo-devo; epigenetics; cortical arealization |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Computer Science (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 Oct 2018 15:37 |
Last Modified: | 03 May 2024 14:33 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.tins.2018.08.002 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:136741 |