Mitchell, DA, Kanatas, A orcid.org/0000-0003-2025-748X, Murphy, C et al. (3 more authors) (2018) Margins and survival in oral cancer. British Journal of Oral and Maxillofacial Surgery, 56 (9). pp. 820-829. ISSN 0266-4356
Abstract
In the surgical management of oral squamous cell carcinoma (SCC) we aim to resect the tumour with clear margins in all planes. The aim of this study was to identify and compare overall survival in a group of 591 patients who had resections, and to relate this to the clearance of margins at the tumour bed. We used life tables to calculate survival at one, two, three, five, and 10 years after diagnosis by margin (clear = 5 mm or more; close = 2–5 mm; and involved = less than 2 mm). Kaplan–Meier curves were produced for the margins alone, which were defined as clear in 480 patients (81%), close in 63 (11%), and involved in 48 (8%). Five-year survival was 81%, 75%, and 54% for clear, close, and involved margins, respectively, which highlights the importance of clear margins for survival. There is a significant prognostic implication associated with close, and particularly with involved, margins.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Oral cancer; margins; surgery; survival; reconstruction; oral squamous cell carcinoma |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > School of Dentistry Visitors (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Sep 2018 11:14 |
Last Modified: | 26 Nov 2018 16:06 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.bjoms.2018.06.021 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:136046 |