Manners, O, Murphy, JC, Coleman, A et al. (2 more authors) (2018) Contribution of the KSHV and EBV Lytic Cycles to Tumourigenesis. Current Opinion in Virology, 32. pp. 60-70. ISSN 1879-6257
Abstract
Kaposi’s Sarcoma-associated herpesvirus (KSHV) and Epstein Barr virus (EBV) are the causative agents of several malignancies. Like all herpesviruses, KSHV and EBV undergo distinct latent and lytic replication programmes. The transition between these states allows the establishment of a lifelong persistent infection, dissemination to sites of disease and the spread to new hosts. Latency-associated viral proteins have been well characterised in transformation and tumourigenesis pathways; however, a number of studies have shown that abrogation of KSHV and EBV lytic gene expression impairs the oncogenesis of several cancers. Furthermore, several lytically expressed proteins have been functionally tethered to the angioproliferative and anti-apoptotic phenotypes of virus-infected cells. As a result, the investigation and therapeutic targeting of KSHV and EBV lytic cycles may be essential for the treatment of their associated malignancies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Molecular Biology (Leeds) |
Funding Information: | Funder Grant number BBSRC BB/M006557/1 BBSRC BB/N014405/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Sep 2018 10:54 |
Last Modified: | 25 Jun 2023 21:30 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.coviro.2018.08.014 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135700 |