Garg, P. orcid.org/0000-0002-5483-169X, Saunders, L.C., Swift, A.J. et al. (2 more authors) (2018) Role of cardiac T1 mapping and extracellular volume in the assessment of myocardial infarction. Anatolian Journal of Cardiology, 19 (6). pp. 404-411. ISSN 2149-2263
Abstract
Although late gadolinium enhancement on cardiac magnetic resonance imaging remains the reference standard for scar assessment, it does not provide quantitative information about the extent of pathophysiological changes within the scar tissue. T1 mapping and extracellular volume (ECV) mapping are steadily becoming diagnostic and prognostically useful tests for in vivo myocardial histology, influencing clinical decision-making. Quantitative native T1 maps (acquired without a contrast agent) represent the longitudinal relaxation time within the myocardium and changes with myocardial extracellular water (edema, focal, or diffuse fibrosis), fat, iron, and amyloid protein content. Post-contrast ECV maps estimate the size of the extracellular space and have sensitivity in the identification of interstitial disease. Both pre- and post-contrast T1 mapping are emerging as comprehensive tools for the assessment of numerous conditions including ischemic scarring that occurs post myocardial infarction (MI). This review outlines the current evidence and potential future role of T1 mapping in MI. We conclude by highlighting some of the remaining challenges such as quality control, standardization of image acquisition for clinical practice, and automated methods for quantifying infarct size, area at risk, and myocardial salvage post MI.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This work is licensed under a Creative Commons Attribution-NonCommercial (CC BY-NC) 4.0 International License. |
Keywords: | magnetic resonance imaging; gadolinium; extracellular space; myocardial infarction; edema |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number BAYER HEALTHCARE L.GB.09.2013.3684 WELLCOME TRUST (THE) 205188/Z/16/Z |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 17 Sep 2018 10:30 |
Last Modified: | 17 Sep 2018 10:31 |
Published Version: | https://dx.doi.org/10.14744/AnatolJCardiol.2018.39... |
Status: | Published |
Publisher: | Turkish Society of Cardiology |
Refereed: | Yes |
Identification Number: | 10.14744/AnatolJCardiol.2018.39586 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135672 |