Spicer, Christopher D. orcid.org/0000-0001-8787-578X, Pashuck, E. Thomas and Stevens, Molly M. (2018) Achieving Controlled Biomolecule-Biomaterial Conjugation. Chemical Reviews. pp. 7702-7743. ISSN 0009-2665
Abstract
The conjugation of biomolecules can impart materials with the bioactivity necessary to modulate specific cell behaviors. While the biological roles of particular polypeptide, oligonucleotide, and glycan structures have been extensively reviewed, along with the influence of attachment on material structure and function, the key role played by the conjugation strategy in determining activity is often overlooked. In this review, we focus on the chemistry of biomolecule conjugation and provide a comprehensive overview of the key strategies for achieving controlled biomaterial functionalization. No universal method exists to provide optimal attachment, and here we will discuss both the relative advantages and disadvantages of each technique. In doing so, we highlight the importance of carefully considering the impact and suitability of a particular technique during biomaterial design.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018, The Author(s). |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 07 Sep 2018 10:30 |
Last Modified: | 26 Nov 2024 00:39 |
Published Version: | https://doi.org/10.1021/acs.chemrev.8b00253 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acs.chemrev.8b00253 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135444 |