Kouroupis, D, Sanjurjo-Rodriguez, C, Jones, E orcid.org/0000-0001-9365-2283 et al. (1 more author) (2019) Mesenchymal Stem Cell functionalization for enhanced therapeutic applications. Tissue Engineering - Part B: Reviews, 25 (1). pp. 55-77. ISSN 1937-3368
Abstract
To date, the therapeutic efficacy of human mesenchymal stem cells (hMSCs) has been investigated in various clinical trials with moderate or in some cases inconsistent results. The still elusive reproducibility relates in part with constitutive differences in the cell preparation, translated into variable “cell potencies”. Other factors include poor cell homing and survival, and age/disease-associated host tissue impairment. It is well accepted that within in vivo niches MSCs exist as heterogeneous cell populations with different stemness propensities and supportive functions. Phenotype-based MSC purification of homogeneous subsets can result in cell populations with distinct biological functions. In addition, preclinical studies have shown that MSC functionalization in vitro, via cell priming, can boost their immunomodulatory, trophic and reparative capacities in vivo. Therefore, in the present review we discuss how phenotype-based MSC purification and MSC priming technologies can contribute to an improved MSC-based product for safer and more effective therapeutic applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018, Mary Ann Liebert, Inc. Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/ten.TEB.2018.0118. This is an author produced version of a paper published in Tissue Engineering - Part B: Reviews. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | mesenchymal stem cells; cellular phenotypes; MSC subpopulations; cell priming |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Experimental Musculoskeletal Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Sep 2018 12:43 |
Last Modified: | 31 Aug 2019 00:41 |
Status: | Published |
Publisher: | Mary Ann Liebert |
Identification Number: | 10.1089/ten.TEB.2018.0118 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:135402 |